讲座题目：小分子探针在药物传递及生物成像中应用 Small molecule-based drug delivery system and its bioimagings

报 告 人：Kim Jong Seung（教授，韩国科学院院士）

时 　 间：2019年9月10日(周二)10:00

地 　 点：中关村校区求是楼425/426学术交流室

主办单位：研究生院、材料学院

报名方式：登录外围滚球app：微信企业号---第二课堂---课程报名中选择“【百家大讲堂】第233期：小分子探针在药物传递及生物成像中应用 ”

【主讲人简介】

Kim Jong Seung教授，韩国高丽大学化学系教授，韩国科学院院士，主要研究兴趣包括靶向药物释放系统的开发，生物荧光成像与老年痴呆综合症的检测与治疗方法研究，主客体化学及杯芳烃化学等领域，近年来在J.Am. Chem. Soc., Angew. Chem. Int. Ed, Chem. Science, Chem. Rev., Chem. Soc. Rev.等国际著名期刊上发表研究论文及综述430篇左右，总引用次数达31500次，个人H-index：93，获得授权专利约70项。

【讲座信息】

  基因组学、蛋白质组学和生物信息学的发展对抗癌药物的开发具有重要的指导意义，可以减少药物滥用，增加安全和特异性的药物治疗。治疗诊断学将治疗与诊断相结合，是一种具有肿瘤选择性靶向、毒性降低、副作用小等优点的药物治疗方法。磁性颗粒、介孔二氧化硅、各种聚合物纳米颗粒的治疗诊断学被广泛认可，具有重要的临床意义。目前，基于共轭荧光化合物在癌症治疗和诊断中受到了广泛的关注。这些结构相对简单、生物相容性好。在这次演讲中，我将介绍在课题组最新的共轭化合物的治疗诊断学的应用及用于肿瘤治疗和诊断。

The advances in genomics, proteomics, and bioinformatics have directed the development of new anticancer agents to reduce drug abuse and increase safe and specific drug treatment. Theranostics, combining therapy and diagnosis, is an appealing approach for chemotherapy in medicine which exhibit improved biodistribution, selective cancer targeting ability, reduced toxicity, masked drug efficacy, and minimum side effects. The role of diagnosis tool in theranostic is to collect the information of diseased state before and after specific treatment. Magnetic particle, mesoporous silica, and polymer nanoparticle-based theranostic systems are well accepted and clinically significant. Currently, small conjugate-based systems have received much attention for cancer treatment and diagnosis. The structural architecture of these systems is relatively simple, compact, biocompatible. In this talk, the latest developments on small conjugate based theranostic agents for tumor treatment and diagnosis using fluorescence undertaken in my lab will be given.